'Nature Genetics' special issue

[Daisy]

I know this is a topic that will probably lead to the thread being pulled but some on this board may be interested.

A special issue of Nature Genetics just came out dealing with human genetic variation. There is nothing specific to track other than the obvious connection.

http://info.nature.com/cgi-bin24/DM/y/e ... Bvi0UWR0Ae


Nature Genetics
Genetics for the Human Race
November 2004, Volume 36 No 11s

Forward
'Race' and the human genome ppS1 - S2
Ari Patrinos

Editorial
The unexamined population pS3

Commentaries
Changing the paradigm from 'race' to human genome variation ppS5 - S7
Charmaine D M Royal & Georgia M Dunston

Forensic genetics and ethical, legal and social implications beyond the clinic ppS8 - S12
Mildred K Cho & Pamela Sankar

What we do and don't know about 'race', 'ethnicity', genetics and health at the dawn of the genome era ppS13 - S15
Francis S Collins

Perspectives
Conceptualizing human variation ppS17 - S20
S O Y Keita, R A Kittles, C D M Royal, G E Bonney, P Furbert-Harris, G M Dunston & C N Rotimi

Implications of biogeography of human populations for 'race' and medicine ppS21 - S27
Sarah A Tishkoff & Kenneth K Kidd

Genetic variation, classification and 'race' ppS28 - S33
Lynn B Jorde & Stephen P Wooding

Will tomorrow's medicines work for everyone? ppS34 - S42
Sarah K Tate & David B Goldstein

Are medical and nonmedical uses of large-scale genomic markers conflating genetics and 'race'? ppS43 - S47
Charles N Rotimi

Assessing genetic contributions to phenotypic differences among 'racial' and 'ethnic' groups ppS48 - S53
Joanna L Mountain & Neil Risch

Implications of correlations between skin color and genetic ancestry for biomedical research ppS54 - S60
E J Parra, R A Kittles & M D Shriver

[tafnut]

Re: 'Nature Genetics' special issue

The only way this thread would get pulled would be if some moron makes unsubstantiated, clearly speculative comments that would show his (ladies rarely indulge in such foolishness) own ignorance on the subject.

[Daisy]

Re: 'Nature Genetics' special issue

>if some moron makes unsubstantiated, clearly speculative
>comments that would show his own ignorance on the subject.

That's what i was expecting in response to the post.

[tafnut]

Re: 'Nature Genetics' special issue

>>That's what i was expecting

which is why I posted the 'rejoinder' before that post was even made.

edit: found in runnersworld.com

"Ethiopian Distance Runners Have Different Genes: We don't pretend to understand this, but new research has shown that Ethiopian marathon runners from the Arsi region have different "Y chromosome haplogroups" than Ethiopians from other parts of the country. The researchers conclude: "Y chromosome haplogroups may play a significant role in determining Ethiopian endurance running success."

[deltre]

Re: 'Nature Genetics' special issue

I may be wrong but I was under the impression that everyone has different genes from everybody else. Or is it DNA? Identical twins? Can anyone help me out?

[Daisy]

Re: 'Nature Genetics' special issue

>I may be wrong but I was under the impression that everyone has different genes
>from everybody else. Or is it DNA? Identical twins? Can anyone help me out?

Think human populations and allele frequencies in populations with respect to the arguments in track and field. Hence the comments from tafnut above.

To address what you wrote above, you are correct. In fact, even identical twins do not have the 'exact' same DNA since there are mutations, due to errors in replication, that can happen after the zygote splits. Not to mention the epigenetic variations due to environmental factors that can cause differences between twins.

[eldrick]

Re: 'Nature Genetics' special issue

>>> edit: found in runnersworld.com

"Ethiopian
>Distance Runners Have Different Genes: We don't pretend to understand this, but
>new research has shown that Ethiopian marathon runners from the Arsi region
>have different "Y chromosome haplogroups" than Ethiopians from other parts of
>the country. The researchers conclude: "Y chromosome haplogroups may play a
>significant role in determining Ethiopian endurance running success."<

this is no surprise - it was suggested in another post that africans living for 1000's of years at altitude would have naturally selected those with "better" genes to deal with the effects of hypoxia at altitude - either arising from a mutation thousands of years ago or just the increasing expression/emergence of a such pre-existing genes (in the genome) thru evolution

an example is the condition called sickle-cell disease in african descended populations (recent descendants) - in the West, in full sicklers it is a serious disease with disabling & potentially fatal effects - but why did it develop ?

apparently sickle-traits give a measure of protection against malaria ( the main killer infection in native africans) - an example of genetics trying to improve someone's chances of survival in a hostile environment

the genes against hypoxia are for a similar reason, but these of-course these have an athletics advantage - they help you run better in distance races compared to traditional sea-level populations

[abinferno]

Re: 'Nature Genetics' special issue

It seems like a lot of you have trouble acknowledging the genetic differences in different races. It remains a fact, some races are genetically more pre-disposed to have talents in one area greater than another race. That's not to say the other race cannot produce a subject capable of matching that talent, just that in general, some races are better than others at various tasks, not just athletics. No one can deny that.

[tafnut]

Re: 'Nature Genetics' special issue

>>No one can deny that.

Who tried?

P. S. Is it just me, or when Daisy commented above that,

"Think human populations and allele frequencies . . . the epigenetic variations due . . ."

why was he dumbing down the nice intellectual conversation we had going?

[Daisy]

Re: 'Nature Genetics' special issue

>>>No one can deny that.

Who tried?

P. S. Is it just me, or when Daisy
>commented above that,

"Think human populations and allele frequencies . .
>. the epigenetic variations due . . ."

why was he dumbing down the nice
>intellectual conversation we had going?


You need a translation? Given your previous discussions in this area i thought this might be about the right level. Take that as a compliment.

[tafnut]

Re: 'Nature Genetics' special issue

>>Given your previous discussions in this area i thought this might>be about the right level. Take that as a compliment.

Let's just say that I 'only' had to use onelook.com two times.