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  • I was on a webinar for Multiple Myeloma today and they clarified the use of the steroid Dexamethasone (Dex) regarding COVID-19. We discussed Dex earlier on this thread.

    Dex is recommended for patients that have tested positive and have symptoms. It reduces inflammation which can reduce coughing, etc.

    However, Dex is not recommended for individuals who do not have COVID-19 because it compromises the immune system making it easier to catch the coronavirus.

    This creates a bit of a problem for Myeloma patients because research shows that Dex makes the top Myeloma drugs more effective. I have been taking it for seven years. But as it happens, for reasons independent of COVID-19, my Myeloma doctors cut my Dex dosage on infusion days in half earlier this year.

    The bottom line is that I am going to have a compromised immune system with or without the Dex. The only question is by how much. All the more reason to be careful about COVID-19.

    Comment


    • Originally posted by jeremyp View Post
      And from Florida:
      "We actually like some of the trends that we've been seeing," DeSantis said. "If you look at the emergency department visits for COVID-like illness, those have been declining since early July. If you look at the hospitalization trends for hospital admissions, those have been declining."
      In another positive sign, the percentage of people who tested positive for the virus was the lowest in two weeks. "We definitely believe that we've seen a peak.NPR

      Oh yeah? A 30% increase in hospitalizations in the last week. Death tolls of 191, 217, 252, 257, in the last 4 days. Great trends, great peak!

      Epidemiologists say that number will keep rising following the surge in cases seen over the past six weeks.

      Jay Wolfson, a public health expert at the University of South Florida, said: "What we're seeing now is the result of the push to open the state. Now we'll have to wait to see if it will level out."NPR
      Last weekend he waited until the Sunday numbers came out and declared that things had "flattened". Of course the numbers typically go down on weekends and thus seemingly always "flatten" until things catch up with the counts on Mondays and Tuesdays.

      Comment


      • Originally posted by NotDutra5 View Post

        Last weekend he waited until the Sunday numbers came out and declared that things had "flattened". Of course the numbers typically go down on weekends and thus seemingly always "flatten" until things catch up with the counts on Mondays and Tuesdays.
        Yes, but the differentials across days has declined over the last 12 days or so, maybe because the test backlog is big enough that the typically low Sunday/Monday (which is actually Sat/Sun data) are getting mid-week data finally. And deaths are not only a lagging indicator, but when you look at deaths on the days that they occur https://mobile.twitter.com/COVID19Tr...622337/photo/1

        The graphic is for Florida, Texas and Arizona deaths. There is a 10-12 day lag between the actual deaths and when they get reported, at least when things are really busy. Not that this will also mean that things will be getting better a bit before the currently-reported deaths do, as it closes part of the gap between reported cases and when deaths occur (of course, there is also the lag between point of infection and test and test and reporting of tests, although positives get reported more rapidly than negatives, at least here in Wisconsin/Dane County when they are really busy).

        Comment


        • This week's episode of PODCAST-19 from 538 has a long piece on Dexamethasone and its history.

          Full podcast - https://fivethirtyeight.com/features...ntial-workers/

          Video on dex - https://fivethirtyeight.com/videos/h...with-covid-19/

          Comment


          • Meanwhile...

            Coronavirus threat rises across U.S.: ‘We just have to assume the monster is everywhere’


            The coronavirus is spreading at dangerous levels across much of the United States, and public health experts are demanding a dramatic reset in the national response, one that recognizes that the crisis is intensifying and that current piecemeal strategies aren’t working.

            This is a new phase of the pandemic, one no longer built around local or regional clusters and hot spots. It comes at an unnerving moment in which the economy suffered its worst collapse since the Great Depression, schools are rapidly canceling plans for in-person instruction and Congress has failed to pass a new emergency relief package. President Trump continues to promote fringe science, the daily death toll keeps climbing and the human cost of the virus in America has just passed 150,000 lives.

            “Unlike many countries in the world, the United States is not currently on course to get control of this epidemic. It’s time to reset,” declared a report released this week by Johns Hopkins University.

            Another report from the Association of American Medical Colleges offered a similarly blunt message: “If the nation does not change its course — and soon — deaths in the United States could be well into the multiple hundreds of thousands.”

            https://www.washingtonpost.com/healt...ge%2Fstory-ans

            Comment



            • After Plummeting, the Virus Soars Back in the Midwest

              States like Missouri, Illinois and Wisconsin are riding a frustrating seesaw during the pandemic, with new coronavirus cases rising again after apparent progress.

              https://www.nytimes.com/2020/08/01/u...es-deaths.html

              Comment


              • Brazil August 1

                Daily new cases 42,578
                Total Cases 2,708,876

                Daily new deaths 1,048
                Total deaths 93,616
                Sunlight is said to be the best of disinfectants

                Comment


                • Originally posted by Halfmiler2 View Post

                  The Saturday (8/1/20) early afternoon numbers:

                  Worldwide: 17,595K(+2%) & 679K(+1%) deaths
                  The USA : 4,668K (+2%) & 153K (+1%) deaths
                  New York: 415K (+0%) & 32,697 (+0%) deaths
                  NYC only: 225K (+0%) & 16,309 (+0%) deaths
                  New Jersey:182K(+0%) & 15,380 (+0%) deaths
                  Bergen Co.: 20,494(0%) & 2,040 (+0%) deaths

                  NJ had 369 new cases and 11 new deaths.
                  NY had 753 new cases and 14 new deaths.
                  NY has 576 hospitalizations.

                  The Rt for NJ rose to 1.44.
                  The Sunday (8/2/20) early afternoon numbers:

                  Worldwide: 17,860K(+2%)cases & 685K(+1%) deaths
                  The USA : 4,705K (+1%) cases & 154K (+0%) deaths
                  New York : 416K (+0%) cases & 32,703 (+0%) deaths
                  NYC only: 225K (+0%) cases & 16,310 (+0%) deaths
                  New Jersey:182K(+0%)cases & 15,836 (+0%) deaths
                  Bergen Co.: 20,521(+0%)cases & 2,040(+0%) deaths

                  NY, NJ, and Bergen total deaths include probable and confirmed deaths. NYC only includes confirmed deaths.

                  NJ had 331 new cases and only 6 new deaths.
                  NY had 531 new cases and also only 6 new deaths.



                  NJ fell to 7th in total cases, falling behind Illinois.

                  The Rt for NJ edged up again to 1.49.
                  Last edited by Halfmiler2; 08-03-2020, 04:23 AM.

                  Comment


                  • meanwhile, in Texas…

                    Houston doctor tells TV station he's fighting both COVID-19 and stupidity


                    https://www.chron.com/coronavirus/ar...k75dabFe4IFKV4

                    Comment


                    • Georgia health workers’ plea to state leadership

                      AN OPEN LETTER TO GOV. BRIAN KEMP

                      https://epaper.ajc.com/popovers/dyna..._share-article

                      Comment


                      • Originally posted by bhall View Post
                        Georgia health workers’ plea to state leadership

                        AN OPEN LETTER TO GOV. BRIAN KEMP

                        https://epaper.ajc.com/popovers/dyna..._share-article
                        Lotsa luck!

                        Comment


                        • Originally posted by gh View Post
                          meanwhile, in Texas…

                          Houston doctor tells TV station he's fighting both COVID-19 and stupidity


                          https://www.chron.com/coronavirus/ar...k75dabFe4IFKV4
                          That guy is on TV more often than Mattress Mack...

                          Comment


                          • Meanwhile....


                            Russia has set a mass vaccination for October after a shortened trial.

                            Russia plans to launch a nationwide vaccination campaign in October with a coronavirus vaccine that has yet to complete clinical trials, raising international concern about the methods the country is using to compete in the global race to inoculate the public.

                            The minister of health, Mikhail Murashko, said Saturday that the plan was to begin by vaccinating teachers and health care workers. He also told the RIA state news agency that amid accelerated testing, the laboratory that developed the vaccine was already seeking regulatory approval for it.

                            Russia is one of a number of countries rushing to develop and administer a vaccine, and it is determined to get there first.

                            Not only would a vaccine help alleviate a worldwide health crisis that has killed more than 680,000 people and badly wounded the global economy, it would also become a symbol of national pride and a valuable propaganda tool for the country that produces it. It could be a lucrative commodity, as well

                            “I do hope that the Chinese and the Russians are actually testing the vaccine before they are administering the vaccine to anyone,” Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases in the United States, warned a congressional hearing on Friday.

                            A Russian regulatory agency is expected to approve that vaccine for the October campaign by mid-August, far earlier than timelines suggested by Western regulators, who have often said a vaccine would become available no sooner than the end of the year.

                            But with limited transparency in the Russian program, separating the science from the politics and propaganda could prove impossible. Critics have already drawn attention to Russia’s tradition of cutting corners in research on other pharmaceutical products and accusations of intellectual property theft.

                            https://www.nytimes.com/2020/08/02/w...-covid-19.html

                            Comment


                            • Originally posted by gm View Post

                              That guy is on TV more often than Mattress Mack...
                              must be a local reference

                              Comment


                              • Many have been of the opinion that for most people they do not even know that they have it or that it is very 'mild' (mild is a designation that sometimes means that they are not hospitalized). However, there is evidence that there is damage to the body that can be significant. Here is a link from Topol's Twitter

                                Many of the people without symptoms don't know they are taking internal hits, such as lung CT abnormalities. So they are both silent infectors and silent infectees. 7/x
                                "Asymptomatic SARS Cov2 and CT Evidence of Lung Injury in > 50%" Lancet Infect Dis June 12, 2020

                                https://mobile.twitter.com/EricTopol...30727791169536
                                H

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