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  • #16
    Originally posted by Conor Dary View Post

    Why are you acting so silly on this?

    Drug promoted by Trump as coronavirus ‘game changer’ increasingly linked to deaths


    Clinical trials, academic research and scientific analysis indicate that the danger of the Trump-backed drug is a significantly increased risk of death for certain patients. Evidence showing the effectiveness of hydroxychloroquine in treating covid-19 has been scant. Those two developments pushed the Food and Drug Administration to warn against the use of hydroxychloroquine outside of a hospital setting last month, just weeks after it approved an emergency use authorization for the drug.

    Alarmed by a growing cache of data linking the anti-malaria drug to serious cardiac problems, some drug safety experts are now calling for even more forceful action by the government to discourage its use. Several have called for the FDA to revoke its emergency use authorization, given hydroxychloroquine’s documented risks.


    “They should say, ‘We know there are harms, and until we know the benefits, let’s hold off,’ ” said Joseph Ross, a professor of medicine and public health at Yale University, who added that the original authorization may have been warranted but new evidence has emerged about the drug’s risks.

    “I’m surprised it hasn’t been revoked yet,” said Luciana Borio, who served as director for medical and biodefense preparedness of the National Security Council and was acting chief scientist at the FDA.


    https://www.washingtonpost.com/polit...9ad_story.html

    I'm not sure how I'm being silly by pointing out that all drugs have side effects and to impugn HCQ because it also does is specious. In my first post on the topic I listed the main side effect that concerns physicians, the lengthening of the QT interval in the cardiac cycle. I was pointing out that this drug is used all the time and is not the poison pill that the media is trying to paint it with, and that 2 of my associates who had COVID19 were treated with hydroxychloroquine. You responded with a reference from the Washington Post. I prefer to get my drug information from the PDR rather than the media.

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    • #17


      Originally posted by bambam1729 View Post

      I'm not sure how I'm being silly by pointing out that all drugs have side effects and to impugn HCQ because it also does is specious. In my first post on the topic I listed the main side effect that concerns physicians, the lengthening of the QT interval in the cardiac cycle. I was pointing out that this drug is used all the time and is not the poison pill that the media is trying to paint it with, and that 2 of my associates who had COVID19 were treated with hydroxychloroquine. You responded with a reference from the Washington Post. I prefer to get my drug information from the PDR rather than the media.
      The media....right..and anecdotal stories.....anyways here is the FDA....


      FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems

      https://www.fda.gov/drugs/drug-safet...tal-setting-or






      Last edited by Conor Dary; 05-19-2020, 06:29 PM.

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      • #18
        And remember this...

        Husband and wife poison themselves trying to self-medicate with chloroquine

        https://www.livescience.com/coronavi...kills-man.html


        Comment


        • #19
          Here is the CDC on chloroquine ....you take it once a week as a prophylactic against malaria...

          https://www.cdc.gov/malaria/resource...hloroquine.pdf

          Comment


          • #20
            Originally posted by Pego View Post

            There is such a thing called professional integrity.
            unacceptable response cut by mods.... don't do it again!
            Last edited by gh; 05-19-2020, 07:25 PM.

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            • #21
              Originally posted by Conor Dary View Post
              F.D.A. Warns of Heart Problems From Malaria Drugs Used for Coronavirus
              The drugs, hydroxychloroquine and chloroquine, have been repeatedly promoted by President Trump. But they should be used only in clinical trials or hospitals, the agency said.
              Is this discussion going to have to be moved to the Darwin Award thread any time soon?

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              • #22
                And here is the PDR reference to hydroxychloroquine sulfate....

                https://m.pdr.net/Mobile/Pages/drug-...e-sulfate-1911

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                • #23
                  Originally posted by bambam1729 View Post

                  I prefer to get my drug information from the PDR rather than the media.
                  Yep. 100%. The drugs I take regularly (along with millions of other folks) have such dire potential side effects, I would never consider taking them if not for my extremely-qualified and experienced physician telling me it would be better to than not.

                  Comment


                  • #24
                    Originally posted by gm View Post

                    Yep. 100%. The drugs I take regularly (along with millions of other folks) have such dire potential side effects, I would never consider taking them if not for my extremely-qualified and experienced physician telling me it would be better to than not.
                    We all do....

                    Nevertheless there is no medical reason for Trump to take hydroxychloroquine....and lots reasons why he shouldn't....that has been pointed out countless times...here is another....

                    Adverse Effects of Hydroxychloroquine, Chloroquine, and Azithromycin


                    The use of chloroquine or hydroxychloroquine and azithromycin to treat or prevent COVID-198 is supported primarily by weak human studies. Because of that, physicians and patients must be aware of uncommon and potentially life-threatening adverse effects of the drugs.


                    https://www.mdmag.com/medical-news/a...e-azithromycin
                    Last edited by Conor Dary; 05-19-2020, 07:17 PM.

                    Comment


                    • #25
                      Meanwhile....is the Canadian Medical Association Journal media?


                      Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the
                      management of SARS-CoV-2 infection


                      Conclusion

                      The use of either chloroquine or hydroxychloroquine and azithro-
                      mycin for treatment or prevention of SARS-CoV-2 infection is cur-
                      rently supported primarily by in vitro data and weak studies involv-
                      ing humans. Physicians and patients should be aware of several
                      uncommon but potentially life-threatening adverse effects should
                      these drugs be used before better-designed studies determine their
                      benefit, if any, in treating or preventing COVID-19. Harms of treat-
                      ment can be mitigated by careful patient selection and monitoring.


                      https://www.cmaj.ca/content/cmaj/ear...00528.full.pdf

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                      • #26
                        Fine by me....


                        Patients With Lupus Experiencing Difficulties Accessing Hydroxychloroquine, Chloroquine


                        https://www.pharmacytimes.com/news/p...ne-chloroquine

                        Comment


                        • #27
                          Originally posted by Conor Dary View Post
                          Why are you acting so silly on this?
                          I think bam’s main point was that the possible side effects are not the only factor that should determine whether to prescribe a treatment authorized by the FDA, a position that is not silly.

                          My non-scientific view is that unless the president has tested positive, it seems unlikely that his case meets the limited scope of the FDA’s Emergency Use Authorization. If this is true then the public announcement of his use of the drug would be very inappropriate.

                          Comment


                          • #28
                            Bambam is correct in saying hydroxychloroquine is used for a long time in other medical conditions other than malaria over time. It is used in Covid-19 cases as an "off label" approval by FDA but only with a physician's consultation with his/her patient. As a child neurologist I had to use many medicines in off label use not with FDA approval because the FDA never/rarely approved drugs for children under a certain age (usually 12-18 yrs old). I only used off label medicines, however, after careful review of my colleagues research papers, discussions with colleagues at meetings and explaining the risks to parents of using a new medicine for their child's serious condition when they had failed in other medicines (e.g. in severe seizure disorders). The FDA still would claim that they did not approve medicine for children and I took the legal risk which was rare years ago because the "national standard" in my specialty was that medical centers and most specialists in my field was using the "off label" drug successfully.

                            That is why there is such a big public fuss over some people take hydroxychloroquine with the consultation and approval with their physician who goes over side effects, risks, and their own medical conditions. They listen to media "experts" who have certain biases and not what they would do if "they or their mother" (the gold standard question one usually ask their physician for advice) came down with Covid-19.

                            Any well respected physician makes decisions everyday on the what is best for their patients and explains the risks and benefits of everything they do day today.

                            Comment


                            • #29
                              Originally posted by wamego relays champ View Post
                              I think bam’s main point was that the possible side effects are not the only factor that should determine whether to prescribe a treatment authorized by the FDA, a position that is not silly.

                              My non-scientific view is that unless the president has tested positive, it seems unlikely that his case meets the limited scope of the FDA’s Emergency Use Authorization. If this is true then the public announcement of his use of the drug would be very inappropriate.
                              I think this is the best overall answer within the thread. I can see taking the medication under the right circumstances, which don't appear to be the case here.

                              Comment


                              • #30
                                As I noted lots of people take it for lupus etc....and have had trouble finding it primarily because people who don't need it are hoarding it...and yes all drugs have side effects...something just about everyone knows...

                                There is little medical evidence to take hydroxychloroquine for C19 and the side effects are serious....

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